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Filtered Search Results
Apexbio Technology LLC AXL1717 477-47-4 250mg
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AXL1717 (CAS 477-47-4) also known as picropodophyllin is a selective inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) tyrosine kinase exhibiting an IC50 of 0 24 0 33 M IGF-1R a transmembrane receptor activated by IGF-1 is implicated in cellular proliferation and survival and its overexpression is associated with various malignancies AXL1717 demonstrates dose-dependent inhibition of cell viability induces G2-M cell cycle arrest and promotes apoptosis in multiple myeloma and colon cancer cell lines In murine xenograft models combination with HDAC inhibitor LBH589 prolongs survival AXL1717 has progressed to phase I/II trials in non-small cell lung cancer
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Apexbio Technology LLC 2'-O-Methylguanosine 2140-71-8 250mg
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2 -O-Methylguanosine (CAS 2140-71-8) is a modified nucleoside generated enzymatically by tRNA guanosine-2 -O-methyltransferase This compound exhibits biological activity by modulating mRNA translation efficiency and interfering with cell cycle regulation through specific signaling pathways In in vitro studies 2 -O-Methylguanosine has been shown to induce apoptosis making it a valuable molecular tool in cancer research It is frequently utilized to investigate apoptosis induction mechanisms and to support the development of novel therapeutic approaches for related diseases
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eMolecules R-TERT-BUTYL 3-CARBAMOYL 10G
5000164653 R-TERT-BUTYL 3-CARBAMOYL 10G
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Medchemexpress LLC 1-octadecanamine, n,n-dimethyl- | 124-28-7 | 97.0% | 250 MG
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Dymanthine (N,N-dimethyloctadecan-1-amine) is an aliphatic tertiary amine supplied as a research reagent for studies of intestinal helminth infestations. It is characterized by a long alkyl chain and a tertiary amine functional group, and is provided at high reported purity for analytical and biological research.
- Chemical name: 1-octadecanamine, n,n-dimethyl-.
- Cas number: 124-28-7.
- Molecular formula: C20H43N.
- Molecular weight: 297.56.
- Purity: 97.0% by NMR.
- Physical state: Solid below 23°C, liquid above 23°C.
- Intended use: Research reagent for studies of intestinal helminth infestations.
- Packaging: available in multiple pack sizes.
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eMolecules ChemScene / Pyrimidine-2-carbaldehyde / 100mg / 441676428 / CS-0048725 / 0.000 / 27427-92-5 / MFCD07778416 / 108.100 / C5H4N2O
ChemScene / Pyrimidine-2-carbaldehyde / 100mg / 441676428 / CS-0048725 / 0.000 / 27427-92-5 / MFCD07778416 / 108.100 / C5H4N2O
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Apexbio Technology LLC BAY 61-3606 732983-37-8 100mg
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BAY 61-3606 (CAS 732983-37-8) is a selective orally bioavailable inhibitor of spleen tyrosine kinase (SYK) displaying an IC50 of 10 nM and a Ki of 7 5 nM for SYK by competitively binding ATP This compound shows minimal activity against other tyrosine kinases such as Src Fyn Lyn Btk and Itk at concentrations up to 4 7 M BAY 61-3606 suppresses Fc RI-mediated degranulation and mediator release in mast cells and basophils as well as Fc R-driven responses in macrophages and neutrophils In preclinical models BAY 61-3606 attenuates inflammatory cell functions and reduces allergic and asthmatic responses supporting its utility in investigating SYK-mediated signaling and inflammation
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Cayman Chemical aLinolenic Acid ethyl ester
An esterified form of α-linolenic acid; increases cyclin E levels and the activity of Cdk2/cyclin E, ERK, and JNK in hepatic stellate cells at 50 μM; inhibits the growth of S. mutans, C. albicans, and P. gingivalis at 25 μg/ml; has been found in biodiesel produced from castor oil using ethanol; has been used as a substrate in lipid peroxidation assays for antioxidant activity
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Selleck Chemical LLC 2.4-Dihydroxypyrimidine-5-carboxylic acid S3127-100mg
2 4-Dihydroxypyrimidine-5-carboxylic Acid (Uracil 5-carboxylic acid Isoorotic acid 5-Carboxyuracil) is an endogenous metabolite
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Apexbio Technology LLC 2'-O-Methyl-5-methyl-UTP 50ul (100 mM)
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2 -O-Methyl-5-methyl-UTP is a chemically modified nucleoside triphosphate analogue designed to enhance resistance to nuclease degradation and improve annealing properties toward complementary RNA sequences Incorporation of this compound into RNA oligonucleotides increases binding affinity to target RNA strands enhances stability under physiological conditions and reduces immune recognition Based on these pharmacological properties 2 -O-Methyl-5-methyl-UTP holds research potential in the synthesis of RNA therapeutics gene silencing projects antisense technology development and other applications requiring long-lasting bioactivity and minimal immunogenic response
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MEDCHEMEXPRESS LLC PROTAC BET DEGRADER-1 5MG
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501872057 PROTAC BET DEGRADER-1 5MG
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Medchemexpress LLC Thiamine hydrochloride | 67-03-8 | 337.27 | 1 ML
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Thiamine hydrochloride is an essential micronutrient serving as a cofactor for many central metabolic enzymes. It activates NrF-2/HO-1 and inhibits TLR4, NF-κB, exhibiting neuroprotective and anti-inflammatory effects. It is utilized in studies concerning diabetic complications, neurological diseases, cancers, and colitis.
- Essential micronutrient and cofactor for central metabolic enzymes.
- Activates NrF-2/HO-1 and inhibits TLR4, NF-κB.
- Exhibits neuroprotective and anti-inflammatory effects.
- Used in studies of diabetic complications, neurological diseases, cancers, and colitis.
- Increases cellular PDH activities and oxygen consumption rate in breast cancer cells.
- Reduces proliferation in cancer cell lines.
- Ameliorates scopolamine-induced memory dysfunction in adult mice.
- Demonstrates anti-inflammatory and antihyperalgesic effects in adjuvant-induced arthritis rats.
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![Medchemexpress LLC Ethanone, 1-(2-pyridinyl)-, 2-(6-methyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)hydrazone | 327031-55-0 | 99.8% | 317.35 | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000439507-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Ethanone, 1-(2-pyridinyl)-, 2-(6-methyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)hydrazone | 327031-55-0 | 99.8% | 317.35 | 250 MG
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Ethanone, 1-(2-pyridinyl)-, 2-(6-methyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)hydrazone | 327031-55-0 | 99.8% | 317.35 | 250 MG
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eMolecules N-FMOC-3-4-PYRIDYL-L-ALAN 5G
5000164407 N-FMOC-3-4-PYRIDYL-L-ALAN 5G
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eMolecules Ambeed / 4-Amino-2-methylpyrimidine-5-carbonitrile / 1g / 552620300 / A178311 / / 698-29-3 / MFCD00084875 / 134.142 / C6H6N4
Ambeed / 4-Amino-2-methylpyrimidine-5-carbonitrile / 1g / 552620300 / A178311 / / 698-29-3 / MFCD00084875 / 134.142 / C6H6N4
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eMolecules ETHYL CYANOGLYOXYLATE-2-O 250G
5000225733 ETHYL CYANOGLYOXYLATE-2-O 250G
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